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Barb Yacos wrote: "what's the scoop on cisapride?" Anetta my wife, PD 12/93 has had continuing constipation problems. She was having problems prior to he diagnosis with PD. At that point she was having success with Metamucil. During our vacation (6 wks on the road) in June '94 she was using Senna Tea (Harvest of Nature - "Herbal Laxative") in the evening and it was working fine. She had not been diagnosed but for 6 months and was on only 3 x 25/100 sinemets a day, and had excellent results until about Aug '94. She was having more difficulty and the internist put her on cisapride (4 per day - before each meal and at bedtime) and chronulac (enulose) ( a mild liquid laxative) as needed up to 2 tablespoons twice a day. She continued the use of Senna Tea and things were pretty good for about a year. She would occasionally add Colace (stool softener). The cisapride did help a great deal with dry mouth. The results were quite consistent until the end of '95. She tried adding HOT prune juice (8 oz) in the evening, but with mixed results. At the time she started the cisapride she started to need more sinemet and it was increased over a period of months and is now up to 6 x 25/100 ( 1 every 3 hours from 5:30 AM on ) and 1/2 50/200 CR at bedtime. 4 months ago Amantidine was added and now the constipation is very severe. She continues to take all the above except prune juice. The cisapride does seem to aid emptying the stomach and getting her medication into the small intestine, which gives pretty consistent uptake of the medications and keeps her "off-times" fairly well under control. We are scheduled to see a new gastroenterologists the end of this month. We hope she has some new ideas. Will keep you posted. Hope this has not been to confusing. ---------------------------------------------------------------------------- ----------------------------------------------------- Woody Schneider Wife Anetta 66 (PD 2 yrs) Derwood, MD [log in to unmask] ---------------------------------------------------------------------------- -----------------------------------------------------