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Yes, Barb, Peter has taken cisapride (Propulsid) for at least a year. I think in the introductory notes to the "constipation Protocol" posted a while back I mentioned that he used it, along with lactulose syrup(Chron- ulac) . He takes 2 tablets about 1/2 hour before each meal, followed in 15 min. by 1 Tblsp. of lactulose. As is true with everything, this regimen doesn't work ALL the time, but it seems to be--for him--a good base from which to operate, and supplement with more drastic measures as needed from time to time. There don't seem to be any noticeable side effects from the "cis",though the lactulose does cause gas. For what it's worth--- Camilla Flintermann,CG for Peter,76/6+