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In a message dated 96-01-18 23:55:16 EST, you write: > >My wife's neurologist told her that he couldn't help >her any more. That she has all the meds that she >should have. She takes 4 sinemet 25/100, 1 eldyprel >2 artane, 3 klonopin a day. The first dose in the >morning lasts about 4 hours. the next doses of sinemet >lasts about 3 hours each. As you can see, she is in >the off state 10 to 11 hours a day. You might want to try going to liquid sinemet with hourly doses that could help smooth things out. Dont count on your neurologist to be in front of the pack, but he or she can help with planning your dosages, at least in my opinion. Regards [log in to unmask]