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Hello, Carol: You ask - >Does anyone remember which year the following medications became available >for prescription.? Sinemet CR, Eldepryl and permax? My Clinical Pharmacology program lists FDA approval dates" Permax - 12/88 Sinemet - 1988 ( I am not sure if this is for Regular and/or CR) Eldepryl - 6/89 Hope this helps. Margaret Tuchman (54/15)