Pat I would be interested to know the name of the neurologist running these two trials. My father is being treated by a neuro at WUMS and has not heard of these trials. Can you tell me what the enrollment criteria are? Don Glaeser At 03:57 PM 1/14/96 -0600, you wrote: >Barb, > >I've been part of the pramipexole study at Washington University in St. >Louis for three years. For me, the principal benefits have been an >improvement in balance, handwriting, and constipation. If I'm "off" when >I take it, I don't go on, but if I'M on, that dose seems to become more >effective, sometimes to the point of causing dyskinesias. I don't notice >much effect of subsequent doses, but I might notice the difference if I >weren't taking it. Hope that helps. > >Pat Schark > >P.S. My neurologist is also heading the tolcapone study, and seems to >feel that's even more effective. > >