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Roberta, My husband and I both agree that I have experienced personality changes as a result of the progression of my PD. Most notable is that I am happier spending time by myself working on things as opposed to always working with others. My desire "to go", to be involved is much diminished. I am content to work at my own pace at home and frequently too tired to participate in evening events. Less anxiety. More relaxed.... Depression was a problem at times prior to diagnosis and still is a problem occasionally..........more of a frustration than a depression..............never had desire to physically harm myself or others. Rita