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Hello Alan read ur msg a little late but nevertheless maybe I can offer some relief to ur wife's foot cramps. Before I started to liquidify my 10/ 25/100/daily Sinemets I suffered greatly frm toe/foot cramps. The formula is 100cc or OJ for each 25/100 pill and divide the sum into the total number of hours from very first dose (which should be a double) till the last. This number will be the number of CC's she can drink each hour. If she comes down too hard from one drink to another...she can tweek the formula by drinking 1/2 the hourly amount every half-hour. I started this method on my neuro's suggestion the first saturday in November. Although not 100% better, its more than 85% WOW Now if I get cramps, they dont last as long. Furthermore, my PD is all in my legs...freezing, stiffness etc. I usually can tell when cramping (might) occur because I get a severe tingling (like your foot falling asleep) At that time I take two ATIVAN and a Motrin IB. The Ativan acts to calm me down and the Motrin is an anti-inflamitory. (BTW) I am slowly substituting the Motrin for Percoset. The Percoset is not an anti inflamitory. PLEASE DO NOT DO ANY OF THIS WITHOUT REFERRING FIRST TO UR NEURO. Hope this will be of some help to her What city to you guys live in. Joyce 51F/11yrs joyce44