Margaret Mates [log in to unmask] zip:63701 age: 62 wt:170 sex:female Yrs.PD 4 (but officially diagnosed:2) Yrs.Meds: 2 Medical indications: Parkinsonian (slow,stiff,sore,tremor) Medications: Carbi-levadopa/L-Dopa (When first diagnosed worked up to 25/100 3 X day. Experimented and found I can get along on 1/4 tab 2 X day.) Sinemet CR (25/100) Have a supply of this and find that by switching between it (1/2tab 1 X day) and the generic I get along OK. No set schedule for switching; sometimes I combine it: 1/2tab Sinemet as first morning dose and 1/4 tab generic. Kind of go according to how my brain and feet are doing. If brain feels "fat" and feet are scuffling and short stepping I switch to what I wasn't taking. It seems like switching makes the meds more effective for a while. My version of a drug holiday.Tremor continues to worsen no matter what the medicine dose and in fact I suspect the meds might be making it worse. Eldepryl (When first diagnosed was up to 5mg 2 X day. Found this drug was causing sore red spots on my gums; stopped taking it.)