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In a message dated 96-01-28 16:08:48 EST, you write: >My older brother retired at 70 and had PD coming on just prior to >retirement. He has been in a wheelchair most of this time pretty much >frozen up between PD & Arthritis. And in a great deal of pain most of the >time. My younger brother is not so bad, Did your brothers both show signs of PD at about the same time (by that I mean in about the same year?) or did they both show signs at about the same age? I would expect (and this is just speculation) that (1) if they had exposure to an environmental agent that contributed significantly to bringing on the disease (e.g. DDT) and (2) they had relatively equal genetic liability/susceptibility to the disease, they perhaps would have onset at about the same time (same year). Of course you can also argue that the genetic component might "put off" the onset in each case until they were roughly the same age. [Perhaps our science update provider, Mr. Bruman, has a reference or 2 on this]. Delana Vaughan