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Alan Bonander: Re your message to Bob Howard - I have read that patients on Sinemet (carbidopa/levadopa) should take at least enough to assure getting at least 75 mg carbidopa and up to 150 mg daily (24 hours). One guide says 100 mg is all most people need. You said target is around 100-150 mg. So it looks like we all agree on something like - no less than 75 mg and no more than 200 mg carbidopa (in Sinemet) daily. What some of us don't know is - what happens if we take too much carbidopa - what are the toxic signs. (I didn't get the message on the listserv which Bob Howard sent re his wife's problem with Sinemet so I am floundering around trying to guess). You are an expert at getting down to the nitty gritty of PD and treatment. Some of us need a course in materia medica but will settle for regular treatment bulletins. Would you get into carbidopa a bit more? In fact consider writing a brand new up to date Parkinsons handbook. We really need one. Regards, Barbara Yacos Hanover NH <[log in to unmask]>