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I am not qualified to respond about medication and drugs. PD seems to vary significantly from individual to individual. For instance, my wife (62.5 & 6) takes three different kinds of Sinemet every 3.5 hrs. (25/100, 10/100, and CR) on empty stomach, followed by Permax (3 times) with food no less than 1/2 hr. later. She also takes other drugs, and suffers from insomnia, constipation, Meniere, etc. and is not always in full control. The important thing is to get a competent doctor who is well acquainted with PD, that you can trust. Our neurologist believes in minimal dosage of medication just enough to function to minimize overdosing and dyskenesia. PD at this juncture can be treated and eased, but not healed. Yet, we do the best we can,...and 'gather ye rosebuds while ye may'. After having a colon resection last week, my wife (and I) are still planning to take a ten day cruise next week, with the surgeon's and neurologist's blessing. Michel Margosis