an abstract that might be of interest:
Acta Neurochirurgica , Vol. 137 , No. 1-2 , 1995
Chronic Anterior Pallidal Stimulation for Parkinson`s Disease
R. P. Iacono, R. R. Lonser, G. Maeda, S. Kuniyoshi, D. Warner, G. Mandybur,
and Sh. Yamada
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Abstract
We present the case of a 51-year-old female who had a four-year history of
Parkinson`s disease with severe "on-off" and disabling progression of
symptoms on chronic levodopa therapy.
After obtaining FDA approval, we implanted a Medtronic deep brain
stimulation lead stereotactically into the right anterior pallidum
contralateral to her most symptomatologic side. Intra-operative stimulation
trials at 100 Hz caused reproducible reversal of akinetic symptoms and
simultaneous microelectrode recording of the posteroventral pallidum
revealed decreased neural activity during anterior pallidal stimulation.
The patient was evaluated pre-operatively and postoperatively using the
Hoehn and Yahr Staging Scale, the Unified Parkinson`s Disease Rating Scale
(UPDRS), videotape, and a computerized data glove. Six months after
implantation, the total UPDRS score was decreased from 68 to 8 and Hoehn and
Yahr Staging improved from 3.0 to 1.5 during periods of chronic high
frequency stimulation. Dramatic improvements in tremor, dystonia,
bradykinesia, and akinesia were noted within seconds of stimulator
activation and were also objectively measured using a computerized data
glove. This case reveals the potential for therapeutic pallidal stimulation
for Parkinson`s akinetic symptomatology.
Keywords: Akinesia; deep brain electrical stimulation; akinesia; globus
pallidum; Parkinson`s disease.
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ron 1936, dz PD 1984
Ronald F. Vetter <[log in to unmask]>
http://www1.ridgecrest.ca.us/~rfvetter/
