I'm new member who has had PD almost 20 years - I got it when I was 40. I'm still doing quite well which should encourage some of those who got it young. Although I have some trouble with "offs" sometimes, I just try to keep a positive attitude and remind myself that it won't last forever! I can still jog and cross country ski - (I skied for 2 1/4 hours this weekend!) One thing i''m taking which might be of interest to others is a natural enzyme called CoQ10 as well as nicotinamide with it. (You can get it at health food stores or in catalogues.) I started aboutthree years ago and it made a huge difference for me. I had much more energy, my voice never got weak a ny more, my "offs" were less severe, my dyskinesia less severe, and in general, i felt 100% better. A lot of people remarked about how well I looked after I started it. There is a study going on now at MIT on it - apparently the doctors know it works, but don't know why or how. I recommend that everyone try it. (It doesn't seem t help everybody)> You should take at least 60mg a day- I take 100. i read an article that said that it works even better with nicotinamide, so I tried that too. Ii think i noiced a difference, although it's been so long ago that I can't remember exactly. While we're on the subject of natural remedies, I also take gingo baloba which is supposed to help brain function. I feel much less "thick" - before I took it I was having a lot of trouble remembering things I just read or heard, and following logical argements in consequence. I suppose it could be all in my imagination, but I really do notice a difference I'd be interested in hearing if other people have had any experience with natural remedies..