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I concur Chuck takes a 3CC SHOT the day he travels overseas, 3 X 1000 pills each day and another SHOT immediately on his return. Normally, he takes 1 X 1500CR B12 daily. He's always UP despite the aggrivation and frustrations I pile on him. THE POINT OF THIS POSTING is that I was having that medicine tiredness and we tried NADH after reading about all its "fine" properties here on the list. After two packages I stopped because to increase from one a day up to 3 or 4 would be toooooo expensive. Chuck suggested I try a month of daily 1000 B12s. I check for any contrary medicine reactions with the RX...he said "go for it" and I did. MAYBE is a plecebo effect but I surely am LESS tired each day....more strength and certainly less nervous. All the things that the label says it will do. Plecebe or not I will continue to take it. So much for NADH. regards joyce