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Report to List from Anne Rutherford [log in to unmask] St John's NF RE: Daily Amount of Permax (pergolide) On Jan 15 I asked the list these two questions re Permax Q1 <<What is the maximum recommended quantity of pergolide (Permax) a day?>> Q2 <<Does anyone take more Permax than I do?>> (I take 5 mg) I would like first of all to thank everyone who sent a reply and those who would have answered if they had the strength. I would also like to say that I am not giving any medical advice. I will hand this information to my Medical Team and I will follow their advice. Please don't make any changes on your own. A word about Permax, it is the commercial name for pergolide--which is a dopamine agonist. In the UK it is known as ?Celance. Dopamine agonists are mostly used with Sinemet (and similar meds) because the effect of the two of them is better than either one by itslf. The other dopamine agonist in regular use is Parlodel ( bromocriptine) which I took for 5 years or so before switching to Permax. I asked these questions because it is almost time for me to climb onto a higher rung on the ladder. And since I only take 2 kinds of medication, (Sinemet and Permax) one of them will be increased. Right now my Permax is at the highest level prescribed by the local doctors! Summary of the answers I received One answer quoted the product information sheet: --In the drug trials the average (mean) therapeutic daily dose was 3mg per day. --The efficacy of Permax at doses above 5 mg/day has not been systematically evaluated." There were eight answers from people giving their own daily amount of permax. One of the eight also reported the amount of permax taken by three others as well as himself. Results note: One reply said 20 mg per day had been suggested for a patient trying to get off another parkinson medication. I don't know if this advice was followed, so I have left this amount off the list. The doses reported are listed below: Daily Permax 0.75mg (reported by self) 0.75mg 2.00mg 2.75mg 3.00mg 3.00mg 3.00mg 4.50mg 6.00mg (reported by another 13.0mg (reported by another It appears that 3.0mg is the popular amount of Permax but there are some who take a lot more. Quite encouraging. I have emailed this message to my Movement Disorder Clinic and will see them in a week or two. Again - my thanks to all who helped Anne Rutherford St John's NF