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My wife, who was diagnosed with PD in 1981, suffers from constipation and regularly uses Milk of Magnesia , which does not work too well.. Her neurologist, on the basis of some research he read, recommended propulsid - 10mg 3 timesa day. We believe that one of the things that happened with the medication was a significant reduction in "on" time and not very much he lp with the constipation. After about a month he has reduced the porpulsid to once a day on the theory that it may very well act as a block to her sinemet. Any one with any experience or knowledge about propulsid and its effect on motility in PD? Thanks. Morris Stein [log in to unmask]