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Moe Stein--re: propulsid (cisapride) . Peter has been using this for nearly a year, and finds it helpful with the chronic and cyclically-recurring constipation of PD. He takes 2 tablets 20-30 min. before each meal, and often also 1 Tblsp. of Lactulose syrup(Chronulac,Duphalac) about 15 min. before the meals. You might want to look at the "Constipation Protocol" which is in the PD archives ( #7875 and 7880 ) for other suggestions, and there is LOTS of stuff in the archives under "constipation" in addition to that. Peter has not felt that the propulsid affcted off time. When he told the neuro that he had heard of it on this list, the doc commented that he was just startingto prescribe it! Good hunting! Camilla Flintermann,CG for Peter,76,6+yrs. Oxford,OH