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TO Morris Stein There are a number of situations which change the therapeutic value of anti-Partinson medications. Here is a partial list of mine. Fatigued: When the body is tired, anti-PD meds do little to change it. Stressed: When I am stressed for what ever reason, I think it changes the Ph balance in the intestine and can significantly change meds value. Constipated: In this case the bowel is blocked. I think the effort of the bowel system is directed to the constipation problem. It may mean that the bowel is shutdown for all I know. I just know that anti-PD meds have minimal value until the constipation is resolved. Under exercised: It is my guess that muscles that are not exercised get little attention when it comes to distribution of anti-PD meds. If the muscles don't need to move, then the signals in the brain don't send the stimulation. This is the use it or lose it problem. Ill with flu, cold, etc.: It seems anti-PD meds do not get the priority or the digestive system is preoccupied with the the affliction. PD gets second or lower priority. Regards, Alan Bonander Age 55, Diag 11 yrs, liquid meds, pallidotomy [log in to unmask]