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Fatigue is very common in PD. I have seen on this list that a good B complex supplement is beneficial. Don't just limit it to B-12. There were some studies about fatigue that I reported on when talking about depression. A study found that 58% of PD patients said, "Fatigue is among my three most disabling symptoms" Fatigue was hghly correlated with depression. It was also found that 67% said "Fatigue with PD was different in quality or severity" than that experienced beforFatigue is very common in PD. There were some studies about fatigue that I reported on when talking about depression. A study found that 58% of PD patients said, "Fatigue is among my three most disabling symptoms" Fatigue was highly correlated with depression. It was also found that 67% said "Fatigue with PD was different in quality or severity" than that experienced before diagnosis. Fatigue was not correlated with disease severity. This says that over half had fatigue associated with depression. If other symptoms of depression also exist then talk to you doctor about it. Depression can be treated. Regards, Alan Bonander Age 55, Diag 11 yrs, liquid meds, pallidotomy [log in to unmask]