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Alan, I experience both occasional leg cramps and practically daily distonia first thing in the morning before my meds kick in, but even though I take 1/2 a sinemet 10/100 twice during the night, it never seems to kick in until I get up and walk around awhile. I try to avoid doing this during the night, because I have this ingrained idea that I'm supposed to lie in bed and sleep during the night. I lie in bed all right, but sleeping more than four hours is a distant memory. Any suggestions? Pat