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I think stress has a LOT to do with PD. My Mom took care of her Mother for 6 years until the day she passed away and it was during that time that she was diagnosed....shortly before my grandmother passed away. To this day I believe if she'd not had all that stress, she'd have not gotten so bad so quickly ...... thank God she's much better at present since changing doctors, but she had gotten VERY bad before we changed physicians.