Roberta Nelson's January 27 message asking about personality changes that may be wrought in PD patients in addition to depression has haunted me now for a long time because somewhere along the line in my own research on PD, I had read about psychopathology in PD patients. Well, I can't seem to put my hands on that; however, I do want to pass along info from two sources on this subject. First, Jankovic & Marsden (1993) have stated that "many PD patients experience a variety of psychiatric reactions, particularly agitation, visual hallucinations, psychosis, paranoia, and hypersexuality." Second, the 3rd quarter 1995 Parkinson Report from NPF had an article about anxiety and PD, which stated "People with PD can suffer from a number of emotional and behavioral disorders. Recent evidence suggests that anxiety is another important behavioral condition which can afflict up to 40% of people with PD. The most commonly described anxiety disorders in PD are panic disorder, generalized anxiety disorder, social phobia and obsessive- compulsive disorder. Anxiety may not merely represent psychological difficulties adapting to the illness, but rather is linked to specific neurobiological processes occurring in PD." The conclusion was that the anxiety of PD sufferers probably reflects some underlying changes in brain chemistry. It would seem likely that personality changes could result whenever you have changes in brain chemistry. It also seems likely that you can suffer from depression prior to PD, with the depression exacerbated by the PD, as Michel Margolis on Jan. 27 inquired about, although I haven't read the articles pertinent to this yet. Does anyone else know anything about this? Marti Eiermann [log in to unmask]