There is a paper by Robert L. Rodnitzky MD ( NEUROLOGY 1992;42(SUPPL 1):44-50) in which he shows the effect of splitting a Sinemet CR. If you break your Sinemet CR in half and take both halves you will get a peak of about 30 per cent more sinemet in your bloodstream than if you take it unsplit and even at the end of 6 hours you will have more sinemet left with the split tablet. It is a good way to get a bit more kick first thing in the morning. from Robert Naylor caregiver & spouse of Olive Naylor ([log in to unmask])