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Alan... I suffered from terrible toe, foot and leg cramps till I began to take a daily vitamin E suppliment. I started with 2000 mg. at noon daily (I begin my daily dose of 2 Sinemet 25/250s at noon also), for one week (tho ALL cramping disappeared withing 36 hours of beginning the vitamin E), and each subsiquent week I dropped off 200 mgs. When I dropped below 800 mgs of vitamin E per day, the cramps came back with a vengence. By increasing the dosage once again to 800 mgs per day there was nothing... no cramps... nada... zip! I've maintained the level of vitamin E intake at 800 mgs per day for 18 months and have suffered no cramps during this time whatsoever. This may not work for everybody, but as my Grandma used to say, "It coulddendt hoit to troy idt." (Errrrrr... ok... OK... not everybody can translate a Russian-Yiddish-English accent ---> "It couldn't hurt to try it!" Barb Mallut [log in to unmask] ---------- From: Parkinson's Disease - Information Exchange Network on behalf of [log in to unmask] Sent: Thursday, February 22, 1996 11:35 PM To: Multiple recipients of list PARKINSN Subject: Pain in PD There have been a number of articles published in the trades on pain in PD. This pain is the stomach, chest, arm, etc. most pain except that of cramps (dystona). In the articles, pain was resolved by increasing the Sinemet. Simple enough but it does the trick. Now there is another type of pain that is associated with depression. It is hard to determine if the pain is a form of depression or a problem in PD. If you recall the paper on depression, it said depression is often masked by chronic and recuurent pain, fatiure, memory loss, sleep problems and sexual dysfunction. Dystonia, cramping in the legs and toes, is said to happen either when one is OFF and has taken meds or one is turning OFF. It seems to be in the up swing and the down swing. No one complains of dystonia when they are ON. Thus I will makea guess -- someone who has toe cramps and leg cramps a lot, is most likely undermedicated. There is one exception that I know and that is someone who may be "carbidopa toxic". This I will explain in another message. Regards, Alan Bonander [log in to unmask]