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For Larry Glenn and James Dooher; On refers to having a correct response to medications, i.e. most sypmptoms gone. Off refers to a lack of response to medication, or re-appearance of symptoms. As time passes, most Parkies become more sensitive to meds like Sinemet, and can experience a rapid shift from the on state to the off state as the current dose of Sinemet wears off. Sometimes, after I take Sinemet, I can be transformed from a stiff, shuffling zombie to a mad dancing fool in a grand total of 30 seconds. Margaret Monty's web page (Top 5% in the Web!!) is excellent, and has lots of links to other useful Parkie Pages: http://ourworld.compuserve.com:80/homepages/pd_digest/ Janet -----Janet [log in to unmask]