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Debra - Welcome. My wife has a very narrow window between too much and too little Sinemet. For the last 3-5? months she has been taking a Liquid mixture of sinemet and Vit. C and water in addition to her reg. meds. (I think some PD's use orange juice.) This helps smooth out her response - it's not perfect, but better. It might help since you take many more small doses. You might alsofind the CARE list useful. You should have received an email through parkinsn from pcflinte..... I hope one or both of the lists are helpful. Phil CG for wife - Carol 59/10