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Everyone has different reactions, but Gordon takes 2 Sinemet 25/100 every two hours, a consistent pattern for years--that obviously is 14-16 a day. He also takes Amantadine(Symmetryl) 1-2 daily, 100mg, and at night 2 Doxepin,10 mg. One of the good results of the Thalomotomy is the Sinemet works very rapidly. Before, it was getting to an hour or more for relief that lasted a short while. Yes,we had tried liqifying it. It helped some, but others on this net seem to have good results with the liquid method.