Found this thread while cruising the net today. Looks like this promising
line of research is getting closer ["...They are about to go to
preclinical trials."] Just wanted to post this for encouragement.
For anyone new to this list, there is info in the archives re GDNF.
_________________________________________________________________
[3]Re: BDNF in Parkinson's
From: [4][log in to unmask] (David Cassarino)
Date: 1996/03/01
MessageID: [log in to unmask]
_________________________________________________________________
sender: [log in to unmask]
x-nntp-posting-host: avery.med.virginia.edu
references: <[log in to unmask]>
organization: uva
newsgroups: bionet.neuroscience
[log in to unmask] writes:
> In article <[log in to unmask]>,
> [log in to unmask] (David Cassarino) wrote:
>
> > I have read that BDNF has been shown in cell culture and animal
> > experiments to protect substantia nigra neurons from death (due
> > to MPTP, OHDA, etc).
> > I was wondering if there have been any clinical trials of BDNF
> > in PD (or Alzheimer's) patients (I tried looking for this on
> > medline but found little).
> >
>
> Amgen is working on GDNF (glial derived). We had a presentation of their
> rat and monkey data last week in out pharmacology seminar. They are about
> to go to preclinical trials. So far the results look promising. GDNF does
> not protect cells from death, rather it increases the neuronal density
> (sprouting perhaps?) and function. The data showed considerable 5HT stain
> recovery and behavioral recovery after GDNF injections following MPTP.
> Obviously Amgen is pitching this towards Parkinson's patients.
>
> David Stout
> UCLA Pharmacology
David,
What importance does the serotonin stain recovery have?
Shouldn't they be looking at DA recovery instead, as this is
the relevent neurotransmitter depleted in PD?
thanks
--
David S. Cassarino "The mind is not a vessel to be filled
MSTP 2nd Year but a fire to be kindled."
UVA School of Medicine -Plutarch
[log in to unmask]
========================================================================
Margaret Monty [log in to unmask]
========================================================================
