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You might try plain old VITAMIN E for leg/toe cramps at night. Start at 2000 mgs. for one week, then reduce intake to 1600 for one week. If cramping return, up dosage. However, if it does't return, further reduce dosage to 1200 mgs. for one week.... if THAT prevents cramping, drpo down to 800 mgs and your hubby should prolly go no lower that that. Barb Mallut, [log in to unmask] ---------- From: Parkinson's Disease - Information Exchange Network on behalf of MRS VIRGINIA CHRISTIANSEN Sent: Saturday, March 16, 1996 12:44 AM To: Multiple recipients of list PARKINSN Subject: Quinine for leg cramps -- [ From: Virginia Christiansen * EMC.Ver #2.10P ] -- I believe I mis-sent this yesterday and apologize if I caused any problems. My husband is suffering from severe leg cramps at night and the doctors have told us Quinine would help. but that it is no longer made available. He is taking tonic water which contains some quinine, but it isn't helping enough.