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>Is there anyone who is trying it as a dopamine agonist? My understanding is >that the nicotine stimulation of dopamine that is described on p. 60 of lst >week's Time magazine may be how NADH (N is for nicotinamide) works. > I have been using NADH since about the same time as Jeff Carper, who says August which sounds right. I went on and off, up and down for quite a while before I was able to adjust my regular meds down far enough to be comfortable after adding NADH. I am currently taking 10 mgs a day, am still at about 60% of my pre-NADH dosage of sinemet. I sleep MUCH better than I have for years, although I had an initial period of gruesome insomnia when starting up. I noticed when I stopped the NADH once way back in the beginning that a stiffness and jerkiness reappeared that I had actually forgotten I used to have! (This short term memory loss is really paying off for me!) Last month I was contemplating increasing from 7.5 to 10 mgs, wondering mainly if benefit might justify the cost (OUCH). I did my famous up and down routine until I determined that on 10 mgs I achieved even better fluidity of motion, and it allowed me to delay the first dose of sinemet an hour or two many mornings. So I'm a 10mg-a-day gal now. I believe the nicotinamide portion of NADH refers to some relationship to vitamin B-3, and I'm certain it does not refer to nicotine. I have a friend who is a pharmacist and I asked her if she had heard of it, and she acted like I was a throwback to the middle ages and said every biology student alive knew what NADH is...apparently it is an integral part of cell energy. BTW, I was swarmed by bees when I was about 7 or 8 yrs old and bee sting therapy will have to come a long way to catch my interest. Be well, Kathie Tollifson [log in to unmask]