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Like Charles Niggley who wrote, ' I cannot disagree with Bill Harper Jr., pharmacist - but my wife reacts differently to the generic' ... I, too, have experienced adverse reactions to generic meds. When I was diagnosed with high blood pressure, I went through a whole raft of drugs before we found one I could tolerate, and some of my reactions were listed as 'rare.' A year or so ago, I was given a generic med. for high blood pressure instead of the brand name which I had been taking for years. When I started having mild, dull headaches and a general feeling that something was not right, I called my doctor and he wrote another prescription for me - NO GENERIC. The headaches, etc. went away. My system is not only sensitive to medications, but drugs that most people can tolerate, I cannot, and vice versa. My doctor told me I was a physician's nightmare, because while most people have a list of drugs they cannot take, he has a list of drugs I CAN take. When I needed my Deprenyl prescription renewed recently, my pharmacist called and asked if I would like one that had recently been approved in Canada because it was much less expensive than the 'Shulman' Deprenyl, but because of my experiences I asked him to check with my neurologist. The neurologist told him I was to stick with the 'Shulman' Deprenyl. My sister, who has a thyroid condition, was given a generic med. instead of the brand name the second time her prescription was filled, and she too ran into difficulties. Her endocrinologist says - NO GENERIC. As someone else suggested, try the generic, but if it causes problems, switch back to the brand name. It is important to be aware of any changes when starting a new medication, and only you know how your body feels. Judith [log in to unmask] London, Ontari