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My husband Jeff, 45/6, has been taking NADH since last August.Together with Eldepryl, Amantadine, Permax (no Sinemet yet) he is doing much better than before. He has been on the Eldepryl and Permax since day 1 but added the other two only since August. Before August he began being extremely tired, the stiffness was considerably worse and overall his condition was deteriorating quickly. Within 2-3 weeks of starting the Amantadine and NADH the overwhelming fatigue was gone. Stiffness and tremor was noticably better. Some would argue the Amantadine, some would argue the NADH is the cause of his improvement. We feel the NADH should get more credit; our 'sense' is that the NADH has made the big difference but we have no way of proving that. Studies are supposed to be starting at University of Pittsburgh Medical Center and I believe a study was done at Harvard/Mass General Hospital, the latter offering promise for NADH and PD. There is quite a bit of information on NADH in the archives; NADH remains controversial and in our own observations it seems to be more effective with tremor, stiffness and fatigue than with falling and the other symptons of PD. Our feeling that it is not for everyone but it does help some including (Jeff) us. There are others who subscribe to this list who are taking or have taken NADH but have not previously spoken up: I hope all of you will answer whether the result is positive or negative. Jeff and I have wondered about the 'nicotin...' in the NADH name and it's possible connection to nicotine in cigarettes since pd seems to occur much less in smokers: it would seem to make sense but until studies are done it is only conjecture. Regards, Lisa Carper P.S. I will privately forward some posts relating to NADH. >I am wondering if anyone has experience with NADH, which is apparently an >MAO-B inhibitor. > >Is there anyone who is trying it as a dopamine agonist? My understanding is >that the nicotine stimulation of dopamine that is described on p. 60 of lst >week's Time magazine may be how NADH (N is for nicotinamide) works. > --