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Dear Robert, I cannot comment on Serzone, but at a recent chapter meeting, the speaker was a psychiatrist who deals mainly with PD patients. He said they have found that Parkinsonians respond better to the older antidepressants like Amytriptolene or Nortriptolene (spellings?) rather than to the newer ones like Prozac, etc. Amytriptolene has a sedative which relaxes muscles and if taken an hour or so before bedtime, has proven to me to provide a more restful sleep. A friend of mine who has been diagnosed with Fibromyalgia, is taking Amytriptplene at bedtime for muscle relaxation also. Depression is a terrible thing and I know first hand what you and Nancy are going through. I don't know if this is of any help to you, but perhaps it is worth mentioning to your physicians. Good luck. Judith ([log in to unmask]) London, Ontario