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Let's be clear on Depression as a clear side effect verses being depressed at having Parkinsons. The later probably ought not to be treated with drugs, unless serious. However, if your Mother suffers depression as a side effect, an anti depressant is certainly not extreme therapyl When I'm off my anti-depressant, I'm feel that life is not worth living, and those around me feel the same also. My depression is so bad, I actually feel painfully naseous. Over the years, I've taken Prozac, Paxcil, and now Serzone. Wouldn't do without one of them. I'm favoring Serzone because for me, the side effects of the first two (Insomnia & Very Low Libido) interfered with the "Normalcy" of my life.