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Authorities seem to disagree on this. The argument for delay is that exogenous dopamine will somehow cause deterioration of the host's natural production, or that it will hasten the onset of dopamine- induced dyskinesia. The argument for starting dopamine immediately is that the patient may as well enjoy the benefits as long as possible; there is no effect on progression of the disease. Ya pays yer money and ya takes yer choice. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403