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Hi: My wife has been diagnosed with PD now for 6 years. She is still working full time. Her current medication is 2 sinemet CR tablets per day (i.e. 2X200/50). She also takes Luvox. Over the last say 6months she has started getting "off" periods in the early afternoon which last until her afternoon medication kicks in. By mid-evening she is very tired and she feels "like a log" by 9:00PM. Her feet and legs get very sore as well by the early evening. Sher has started taking a 1/2 CR in the early afternoon and then a full one around 5:00PM but this doesn't seem to help much. Does anyone have some suggestions? This constant fatigue in the evening is very dispiriting for her. Norm Ichiyen