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In message <[log in to unmask]> Parkinson's Disease - Information Exchange Network utoronto.ca writes: > Ron Reiner ([log in to unmask]) 48 + 7mos PD wrote: > <<I (as well as a lot of other recent diagnosees ) am making every attempt > to delay starting Sinemet as long as possible. Am I deluding myself? > > Have there been any formal studies on this issue?>> > > There are few formal studies - and there will be none that are not > confounded by the use of varying dose and added medications that cover a > number of years. > > I consider it foolish to delay use of the only available medication that > does the best job by far in replacing the deficit in neurotransmitter > dopamine. Ron is not the only Parkinsonian doing this delaying - and there > seem to be numerous advocates that recite that deprenyl or some other > expensive pill was sufficient to reduce symptoms allowing delay in starting > laevo-DOPA. > > The minimization of medication amount always makes sense. (This is from > the patient's point of view. NOTA BENE: the drug manufacturer is in > business to maximize his income. Let the buyer beware!) > > I challenge the drug companies or the pharmacists or clinicians to present > the data that show any benefit in using any other drug first or in delaying > the usage of levodopa. (I anticipate no response.) > > ron 1936, dz PD 1984 > Ronald F. Vetter <[log in to unmask]> > http://www1.ridgecrest.ca.us/~rfvetter/ I concur that there is no good evidence at this time that the delaying of the onset of taking levodopa ( sinemet) is helpful. Take what you need to feel your best ! Bob Howard, MD Bob Howard, occasionally known formally as: Robert B. Howard <[log in to unmask]> 1320 Wisconsin St. Hudson, WI 54016 Voice phone (714) 386 3596