To Phyllis Riely and list members: In response to Phyllis's question, I have been on Sinemet and prednisone at least twice, both times for chest congestion due to a flu' or viral infection which resulted in asthmatic-like symptoms which seemed to respond only to the prednisone. I noticed an increased feeling of well-being while on the prednisone -- stronger, increased appetite, more energetic, and I slept better at night. Going off the prednisone was another matter -- even tho' I "tapered" the dose down, I experience fatigue, headache, nausea. This occured both times, and was an expected reaction. At that time I was taking one half pill sinemet 100/25 every 3 hours (total 300 mgs a day), accompanied by permax 1 mg (total dose 4.0 mg daily) and tolcapone (200 mg every 6 six hours). I am 49 years old, and was diagnosed in 1988, but experienced symptoms several years prior to diagnosis. Hope this helps. I have been "lurking" on this list for some time -- and finally have a chance to contribute. Sharon Shell([log in to unmask])