 |
 |
My wife, Barbara, had terrible nausea when initially on Sinemet CR and now does not usually have a problem. It does recur if the dosage is increased. In the book, "Parkinson's Disease" by Roger Duvoisin, MD it says: "There is a specialized area located in the brainstem....Here is the vomiting center. It contains nerve cells whose task is to detect toxins...in the circulation and to prevent further absorption...by provoking vomiting to emprty the stomach and throw out the offending material. "The vomiting center is sensitive to levodopa...As the blood level of levodopa rises approximately 30 minutes after a dose, the vomiting center may be activated.....The vomiting is not due to irritation of the stomach itself.........After repeated exposure to levodopa the vomiting center gradually becomes accustomed to its presence and no longer responds to it.....It is possible to tame the vomiting center....by taking levodopa only after meals to slow absorption." Hope this is encouraging.