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Hi Bill, I read Alan's reply to your query and I agree with what he says. Ive been on L>S> since November and although I tried to change the dosage from 10 25/100's to 9, I wound up back with 10. I take a double dose at 0600 and again at 8PM which I know is slightly ahead of my "regular" OFF times. Sometime during the month according to my cycle I am forced to drink a 1/2 dose each 1/2 hour a few times a day for a pick-me-up (no pun). The most difficult part of this method is trying to work around meals....but to be honest, my meals are more important and its almost impossible to time it so perfectly. Good luck and Ill continue to monitor your comments. Joyce