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[log in to unmask] wrote: > > I have not been able to resolve the question about the efficacy of Sinemet > over time. It has been stated that the administration of Sinemet should be > delayed as long as possible so as to defer the eventual loss of effectiveness > of the drug. > Question: > (1) Is this loss of efficacy due to built up immunity against the drug over a > span of five or so years? Or > (2) the drug becomes ineffectual because of the advance of the disease so > that nothing would help at that point? > (3) If Sinemet is initiated at a likewise advanced stage of PD, would it be > efficatious at all? > > I am still baffled by the complexities of this disease. And we do the best Michel, Good questions! However I do not believe the answers to your questions are known. I think the effectiveness of Sinemet would still be there in the advanced stages of the disease. There is some experimental evidence on animals that would suggest that Sinemet is in fact a contributing cause of the advance of the disease. Animal studies have shown that Sinemet causes free radicals to form throughout the brain. Personally I think it is good advice to delay taking it and the when you do begin, be sure that you take antioxidents. --- Milo -- Milo V. Anderson, Ph.D. Box 417 Angwin, CA 94508 voice 707 965 2508 fax 707 965 3148 e-mail [log in to unmask]