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>[log in to unmask] wrote: >> >> I have not been able to resolve the question about the efficacy of Sinemet >> over time. It has been stated that the administration of Sinemet should be >> delayed as long as possible so as to defer the eventual loss of effectiveness >> of the drug. >> Question: >> (1) Is this loss of efficacy due to built up immunity against the drug over a >> span of five or so years? Or >> (2) the drug becomes ineffectual because of the advance of the disease so >> that nothing would help at that point? >> (3) If Sinemet is initiated at a likewise advanced stage of PD, would it be >> efficatious at all? >> >> I am still baffled by the complexities of this disease. And we do the best > >Michel, > >Good questions! However I do not believe the answers to your questions >are known. I think the effectiveness of Sinemet would still be there in >the advanced stages of the disease. There is some experimental evidence >on animals that would suggest that Sinemet is in fact a contributing >cause of the advance of the disease. Animal studies have shown that >Sinemet causes free radicals to form throughout the brain. Personally >I think it is good advice to delay taking it and the when you do begin, >be sure that you take antioxidents. >--- Milo >-- >Milo V. Anderson, Ph.D. >Box 417 >Angwin, CA 94508 > >voice 707 965 2508 >fax 707 965 3148 >e-mail [log in to unmask] > Milo, Do the standard A,C, and E antioxidents cross the blood/brain barrier? If so, how well? Peace. John