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Does anyone recall how rapidly PD progressed before Sinemet was available? Miriam L. Denham [log in to unmask] On Sun, 21 Apr 1996, John Morey wrote: > >[log in to unmask] wrote: > >> > >> I have not been able to resolve the question about the efficacy of Sinemet > >> over time. It has been stated that the administration of Sinemet should be > >> delayed as long as possible so as to defer the eventual loss of effectiveness > >> of the drug. > >> Question: > >> (1) Is this loss of efficacy due to built up immunity against the drug over a > >> span of five or so years? Or > >> (2) the drug becomes ineffectual because of the advance of the disease so > >> that nothing would help at that point? > >> (3) If Sinemet is initiated at a likewise advanced stage of PD, would it be > >> efficatious at all? > >> > >> I am still baffled by the complexities of this disease. And we do the best > > > >Michel, > > > >Good questions! However I do not believe the answers to your questions > >are known. I think the effectiveness of Sinemet would still be there in > >the advanced stages of the disease. There is some experimental evidence > >on animals that would suggest that Sinemet is in fact a contributing > >cause of the advance of the disease. Animal studies have shown that > >Sinemet causes free radicals to form throughout the brain. Personally > >I think it is good advice to delay taking it and the when you do begin, > >be sure that you take antioxidents. > >--- Milo > >-- > >Milo V. Anderson, Ph.D. > >Box 417 > >Angwin, CA 94508 > > > >voice 707 965 2508 > >fax 707 965 3148 > >e-mail [log in to unmask] > > > Milo, > > Do the standard A,C, and E antioxidents cross the blood/brain barrier? If > so, how well? > > Peace. > John >