HI Betti The following is taken from "A Symmary of Medications Both Commonly and Occasionally Used in Treating Parkinson's Disease by Neal Slatkin MD", a paper that is a reprint of most of the City of Hope Parkinson's Center Newsletter, "Moving Forward, Summer 1995", that was previously place on the Parkinson's listserv. I am unsure as to why beta blockers would "occasionally" limit the effectiveness of levodopa. Hopefully someone else does! Brian Symonds <[log in to unmask]> MEDICATIONS AND OTHER AGENTS OCCASIONALLY USED TO TREAT ASSOCIATED PROBLEMS OF PARKINSON'S DISEASE BETA BLOCKERS Inderal (propranolol), Tenormin (atenolol) and others Beta blockers are of no direct value in the treatment of PD symptoms and may occasionally limit levodopa effectiveness. Some patients with PD, however, have an action or intention tremor brought on by elevation or movement of their arms and which is different from their usual rest tremor. This tremor can at times be reduced in severity by the use of beta blockers. Side Effects of Beta Blockers * Fatigue, nausea and vivid dreaming * Occasional reports of increased forgetfulness * Wheezing, difficulty breathing, fatigue Contraindications to Beta Blockers Patients with a history of congestive heart failure, slow heart rate, asthma, bronchitis or emphysema; and people with diabetes who are taking insulin usually should not take beta blockers. Patients on this class of medication should know how to take their own pulse and should contact their physicians if their pulse rate falls below 50-60 beats per minute.