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A few members of my local (Santa Barbara, CA) PD Support Group reported that nausea induced by Sinemet has been greatly reduced if you cheat just a little and have a few crackers or a light snack with the medicine. Another suggestion was to take Sinemet with orange juice. It was claimed that OJ helps the absorption of Levodopa. I can't vouch for these approaches, not having suffered from nausea myself (mercifully) from any PD medication. Thought I'd share these pointers that have helped others and might just help you, Dora, Kathy and futre early sinemet users. Best wishes. Hope this helps someone. Ilan Levi ([log in to unmask])