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It takes skilled statistical analysts to draw safe and sound conclusions from retrospective studies. Medical statistics compound the felony further. Variations in disease syndromes/ patient catagories (gender,age,race)/environment/climate/ geography/personality (A-B type,etc.) or even the statistician, perhaps, casts a light-beam across the data. The December,1995 British Medical Journal report that patients taking Eldepryl with their Sinemet had higher mortality rate, or deceased at an earlier age, than those using Sinemet without Eldepryl sent a murmur of doubt around the "Online" world. Recent glimmerings from Grateful Med assure us that the probability of this being a fact is now being probed, tested, analyzed, and given a full examination. Studies showing variations in reaction to all the above mentioned factors are delineated in searching the Medline. Will cite studies on request. So let's settle down and take our medicine until our doctors tell us otherwise... . mary manfredi(Mehmoirs)