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Hello Dawn, the reply you received from Gordon Seece is quite accurate. Ive been on LS since November and I can give you my "prescription" 10 25/100 per day each 25/100 = 100ml/cc of OJ. OJ seems to breakdown the pills water does not. so, 10 25/100's into 100ml/cc I do not add ascorbic acid anymore, it made my stomach upset I have recently begun to add two packages of Sweet and Low (substitute sugar) to add a little sweetness to the acid juice. MUCH BETTER TASTING. Since my first dose is at 0600 and my last about 20:00 counting the 0600 as a dose, the total hours are 15. As Gordon said, both he and I double dose at 0600 as a kick start. ( I found that is better to eat something at that time also...toast, dry cereal etc. It prevents a bad stomach.) That brings the total hours to 16. 1000ml */* 16 = roughly 60ml/cc per hour. Sometimes my symptoms (freezing, foot/leg cramping) are bad, so I take a 1/2 dose drink every 1/2 hour. It seems to reduce the symptoms and make them not last as long. Its difficult to live by the clock, however, If you are eating around the top of the hour, or its inconvenient, dont worry, Just double up when its convenient. As long as you finish the bottle each night its ok. BTW its better when the drink is cold. Almost forgot, sometimes my stomach acts up because of the acidity. On those days, I swig a little MYLANTA or any (ANTI GAS, STOMACH COATING LIQUID) three times a day. Hope this help a little, where are you in Australia?? regards Joyce