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Demerol (or any related opioid analgesic) is definitely not to be combined with Eldepryl (or any other MAO inhibitor). The mechanism of reaction is uncertain but it is severe and can be fatal. See the PDR articles on both drugs. As for Demerol with Sinemet, there is no specific warning, but Demerol by itself can be dangerous. Sinemet with MAO-A inhibitor (not Eldepryl) is also dangerous, but that isn't the question here. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403 On Thu, 2 May 1996 [log in to unmask] wrote: > Could Demerol have this same effect on someone taking Sinemet, Sinemet CR, > and Parlodel? >