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In reply to the inquiry about constipation, it's common in PD. I was troubled with it to the point of needing a laxative, but when I raised my daily dosage of Sinemet the constipation went away. I have read that dopamine is needed in the gut as well as the brain, and when the gut doesn't have enough, it is essentially paralyzed. Try this (with your neuro's approval) and good luck. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403