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I am not the expert Joe was asking for, but rather the experienced patient. I had a very difficult time with curling toes and feet (dystonia) for about six months last year....occurring 35-45 minutes after taking a CR......I was takin 6 per day (50/200). I was switched to 10/100's and replaced one CR with two 10/100's every three or four days.....to a total of 1 CR and 6 10/100's and 1 25/100 per day. The dystonia magically ended on the day after I reached a level of 150 carbidopa.....I have never again experienced dystonia that is disabling as this had become. Rita Weeks